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Tramadol is a synthetic opioid that belongs to the aminocyclohexanol group having opioid agonist and analgesic properties. It targets opioid receptors in the brain and alters the neurotransmission of 2 neurotransmitters i.e. serotonin and noradrenalin which overlap pain, mood, stress, and sleep. You can order Tramadol cash on delivery or buy cheap Tramadol pills online from various pharmaceutical sites after uploading the valid doctor’s prescription on the site.
Tramadol is a centrally acting weak opioid agonist, which gets metabolized via certain enzymatic action pathways. A recommended Tramadol dose can be administered orally, intravenously, rectally, intramuscularly, subcutaneously, and spinally. Patients suffering from postoperative pain are often given intravenously or intramuscularly Tramadol dosage. The main concern with prolonged Tramadol use was related to body dependency, which results in Tramadol abuse and addiction. To counter this effect, controlled-release tablets and capsules were introduced which are easily available online in required Tramadol dose and strength. You can easily order Tramadol online or buy Tramadol COD online by uploading a valid doctor’s prescription. Tramadol use and the safety profile was also assessed with non-opioid analgesics especially with paracetamol, which gave results in favor as the combination proved to give improved analgesia by not increasing toxicity level. For more information on Tramadol use with non-opioids combination consult your doctor.
Tramadol has a relatively safer profile and can be used until 6 months for managing pain. However, its long-term use can increase the risk of tolerance, physical and emotional dependency and can also cause serious Tramadol side effects like dizziness, dry mouth, nausea, sedation, and sweating. In a few people, Respiratory depression is also observed after Tramadol intravenous administration.
If you have ordered Tapentadol COD online, it is delivered with a pharmacist’s medication guide on how to consume the medication. It is recommended to read the medication guide before you take the tablet or capsule. If any questions regarding the use of the medication persist, it is recommended to ask the doctor.
Tramadol medication is usually taken orally by mouth after every 4 to 6 hours or as directed by the physician to relieve pain. The dosage of the medication is based on the medical condition and the response of the patient to the treatment. This drug can be taken with food or without it. Usually, the doctors prescribe the maximum dosage of 400 milligrams per day to healthy adults. It is strictly recommended not to increase the dosage of the medication or consume it for a longer duration than prescribed by the doctor to prevent adverse effects.
Like all opioids drugs, people who take tramadol for a long time develop withdrawal symptoms if the doctor reduces the dosage or they stop taking the drug altogether. The withdrawal symptoms include restlessness, excess sweating, generalized anxiety, aches and joint pain insomnia, and increased blood pressure and heart rate.
The prolonged use of opioid analgesic medications is not recommended during pregnancy and the lactation period. It results in physical dependence in the neonate. The medication can affect the childbirth process. Many cases of neonatal seizures, neonatal withdrawal symptoms, and death have been reported with the prolonged use of tramadol.
Lactating mothers should also avoid intake of tramadol. The infants can be subjected to respiratory problems and other health issues if the lactating others are using tramadols.
Tramadol has been given a Schedule IV analgesic status while Tapentadol, by comparison, has been given Schedule II drug analgesic status for the treatment of acute to chronic pain. A detailed comparison on Tramadol vs Tapentadol has been depicted below in the table.
| Classification | Tramadol | Tapentadol |
| Version and Nature | It is an old version which requires active liver enzyme for its metabolism (Pro-drug) | It is New and improved version of tramadol which does not rely on any enzymatic action for its working as it is an active drug |
| Released date and mechanism of Action | The drug was released in 1977 and has multi-mode of action | Released in 2008, Tapentadol has a dual mechanism of action |
| Side effects | Nausea, vomiting, constipation, light-headedness, dizziness, drowsiness, or headache | headache, heartburn, stomach pain, dry mouth, excessive tiredness, anxiety, drowsiness, difficulty falling asleep or staying asleep, abnormal dreams, irritability, a sudden feeling of warmth |
| Opioid activity, Dose value, and the onset of action | Being a Weak Opioid it requires 60 min time to deliver its action. It is available in 25 to 100 mg which can be taken at an interval of every 4 to 6 hours | As a Potent Opioid, it requires only 32 min time to deliver its action. Its lower dose is efficient and effective as compared to the Tramadol dose. It is available in 50-100mg form which can be taken at an interval of every 4 to 6 hours |
| Evidence for use | osteoarthritis, neuropathic pain, and cancer pain | orthopaedic, cardiac surgery, chronic low-back pain, cancer-related pain, and neuropathic pain |
Tramadol and Tapentadol are opioid agonists, which are used to prevent moderate to severe pain and are also used to manage discomfort caused due to it. Tapentadol being an advanced version of Tramadol is more efficient, although they both are opioids tramadol is weaker than Tapentadol.
Both Tramadol and Tapentadol inhibit the reuptake of neurotransmitter norepinephrine roughly with the same efficiency but serotonin reuptake inhibition by Tramadol is 3 times more than Tapentadol which makes Tapentadol a better option in term of superior analgesia and fewer chances of serotonin-related toxicities.
Tramadol for sale or Tapentadol for sale option offer cheap & genuine pills which are used for treating moderate to severe pain and in some cases; it can be also used to treat high-intensity pain. People can order Tapentadol online or buy Tramadol 100 mg online from any reputed online pharmacy store at your convenience. You can avail of exclusive discounts and benefits simply by registering with our pharmacy. Our store offers a safe and timely delivery of genuine Tramadol pills online. After ordering online your medicines will be delivered safely to your doorsteps.
While placing your order for Tramadol and Tapentadol 100 mg online make sure to choose an authentic website. Reputed online pharmacies are always good to go as they are FDA approved and follow the guidelines set by the government. Make sure to get hold of a valid prescription as you will be asked to upload the prescription before placing an order from these reputed sites you cannot order Tramadol without prescription or buy Tapentadol without prescription.
Patients who are more sensitive to an adverse side effect of opioids like fatigue, sedation, and constipation can order Tramadol 100 mg online as it is mild and cause fewer adverse side-effects. For a safer selection of Tramadol or Tapentadol online order always go for cash on delivery option. With the COD option, you can pay at the time of delivery only in cash.
